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- $Unique_ID{BRK02013}
- $Pretitle{}
- $Title{What is Lupus?}
- $Subject{lupus inflammatory disease connective tissue systemic lupus
- erythematosus SLE disseminated LE muscles joints arthritis pleurisy lungs
- kidneys kidney strokes stroke seizures seizure psychiatric actions nervous
- system rash rashes hair loss fatigue immune system autoimmune antibodies birth
- control pills menopause female hormones corticosteroids inflammation bacterial
- infections bacterial infection diet stress sun light}
- $Volume{}
- $Log{
- Immune Cell Production Sites I*0004501.scf
- Immune Cell Production Sites II*0004502.scf
- Humoral Immunity*0004601.scf
- Cell-Mediated Immunity*0004602.scf}
-
- Copyright (c) 1993 Tribune Media Services, Inc.
-
-
- What is Lupus?
-
-
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-
- QUESTION: I don't think I have ever seen you write anything about lupus,
- although I read your column faithfully whenever it is printed in our paper. I
- know this is a difficult disease to describe, but our family has such need for
- information about this problem, that I was delegated to write to ask for your
- help. Would you please describe the disease and what we can expect to happen
- to our sister in the coming years? I can't tell you how much we would all
- appreciate your help.
-
- ------------------------------------------------------------------------------
-
- ANSWER: There are varying forms of this inflammatory disease which affects
- the connective tissue in the body, that can run from a mild type to a severe
- form that requires immediate treatment. It is known as systemic lupus
- erythematosus (SLE) or disseminated LE. The disease is often difficult to
- diagnose, for it can affect almost every organ in the body, and can produce a
- wide variety of symptoms. When muscles and joints become inflamed and
- painful, the disease resembles arthritis. It can produce a shortness of
- breath and pain that looks like pleurisy when it attacks the lungs, cause a
- variety of symptoms when affecting the kidney, and provoke strokes, seizures
- and psychiatric actions when the nervous system becomes involved. Rashes are
- typical; especially a rash that bridges the nose and resemble a "butterfly",
- as well as painless sores in the mouth and nose, and hair loss. In many
- cases, none of these situations are readily apparent, and the patient
- complains only of fatigue, just not feeling up to par. The disease is far
- more frequent in women than in men, as almost 90 percent of the cases are
- women. Black women are more affected than their white counterparts.
- SLE is a disease of the immune system, an autoimmune disorder that occurs
- when the body turns against itself. The immune system produces antibodies
- that react against the bodies own tissues, rather than foreign substances,
- like bacteria, that invade the system. This is probably caused by two things;
- an inherited predisposition to the disorder, and a second precipitating cause
- in the environment, like a virus or exposure to toxic chemicals. Since women
- are affected in such high numbers, hormones may also play a role. Birth
- control pills can make the condition worse, and lupus often gets a bit better
- after menopause, when the body stops producing female hormones. It is also
- possible that lupus is not merely a single disease, but comes from a number of
- things happening at once.
- The use of corticosteroids remains the standard treatment to reduce the
- amount of inflammation, and to reduce the severity of the symptoms. Once the
- condition comes under control, the amount of medication is reduced gradually
- over a long period of weeks or months. Other medications that suppress the
- immune system may also be used, but then close attention is paid to the
- possibility of infections. With the immune response held at bay, bacterial
- infections can rapidly establish a foot hold, which can complicate the
- treatment and the life of the patient.
- Diet, reduction of stress, and avoiding excessive sun light are also
- advised, to help reduce both the frequency and severity of the "flares",
- periods during which the disease becomes more intense. Research has provided
- a number of therapies that provide a person with a normal life-span, and
- continues today to seek even more definite and affective treatments. You,
- your sister, and your family can obtain a wealth of information from the Lupus
- Foundation of America, Four Research Place, Suite 180, Rockville, Maryland,
- 20850-3226.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-